// Temporal dynamics of contextual processing in the inferior colliculus of a rat model of autism: Sex- and age-dependent trajectories
本研究探討性別、發育與產前丙戊酸（VPA）暴露對大鼠腦幹聽覺處理的影響｜採用單神經元記錄分析聽覺預測與重複反應，發現女性成熟過程中預測誤差信號增強且反應時延長｜VPA暴露則破壞此性別與年齡相關模式，尤其影響女性｜結果突顯聽覺處理之時間動態重要性，暗示早期腦幹迴路與自閉症感覺差異相關。
// This study investigated how sex, development, and prenatal valproic acid (VPA) exposure affect auditory processing in the brainstem of rats. Using single-unit recordings with oddball and cascade paradigms, the researchers analyzed components of auditory prediction and repetition responses. They found that maturation reorganizes auditory processing in females, enhancing prediction-error signaling and lengthening response times, while VPA exposure disrupts these sex- and age-dependent patterns, especially in females. These results highlight the importance of temporal dynamics in auditory processing and suggest early brainstem circuits contribute to sensory differences related to autism.
Published 2026年5月18日
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