Grn在鼠耳蝸核突觸發育中的作用

// The role of Grn in the development of mouse cochlear nucleus synapses

本研究探討前膠質素（Grn）在小鼠耳蝸核（CN）突觸發育中的作用｜Grn缺失小鼠聽覺閾值與神經元數量正常，但突觸點密度和聽覺腦幹反應（ABR）第二波幅度顯著下降｜結果顯示Grn對CN突觸功能關鍵，缺失則導致中樞聽覺突觸病變。

// This study investigated the role of progranulin (Grn) in mouse cochlear nucleus (CN) synapse development. Using Grn knockout and wild-type mice, auditory brainstem responses and immunofluorescence analyses showed that Grn deficiency did not affect hearing thresholds or neuron numbers but significantly reduced synaptic puncta density and ABR wave-II amplitudes. These findings reveal that Grn is crucial for synaptic function in the CN and that its loss leads to central auditory synaptopathy.

Published 2026年5月20日