氨基糖苷類藥物耳毒性導致之語音噪音辨識困難反映感覺傳入與傳出功能障礙合併

// Speech-in-noise difficulties in aminoglycoside ototoxicity reflects combined afferent and efferent dysfunction

本研究探討囊性纖維化患者使用氨基糖苷類抗生素後的語音噪音辨識困難｜透過聽力測試發現標準頻率（SF）聽力損失，而非擴展高頻（EHF）損失，與語音辨識能力下降相關｜研究指出聽覺感覺與神經損傷並存，建議預防和治療需同時針對這兩種機制進行。

// This study investigated speech-in-noise (SiN) perception difficulties in cystic fibrosis patients treated with aminoglycosides, focusing on cochlear and neural damage across extended-high-frequency (EHF) and standard frequency (SF) ranges. Using audiometry, otoacoustic emissions, and middle ear muscle reflex tests on 101 CF patients and 84 controls, they found that SF hearing loss, not EHF loss, mainly predicted poorer SiN performance, with increased efferent neural activity also linked to difficulties. The findings highlight combined sensory and neural damage as key contributors to SiN challenges in CF, suggesting prevention and intervention should address both mechanisms.

Published 2026年5月22日