計算聽覺周邊模型：囓齒動物的回歸

// Computational auditory periphery models: The return of the rodent

本研究將人類非線性耳蝸傳輸線模型調整應用於老鼠與沙鼠｜模型通過實驗數據驗證，成功模擬聽覺神經響應與耳蝸調諧，但在耳蝸基底與頂端處存在誤差｜模擬重現動物研究中的聽覺神經突觸病變效應，雖然外毛細胞損傷個體化建模準確度較低｜此跨物種模型有助於解析動物數據並推動聽力損失機制的計算研究。

// This study adapted a nonlinear cochlear transmission-line model originally for humans to mice and gerbils by adjusting species-specific anatomical and physiological parameters. The adapted models were validated against experimental data, showing reasonable matches in auditory-nerve responses and cochlear tuning, though discrepancies appeared near cochlear base and apex. Simulations reproduced auditory nerve synaptopathy effects seen in animal studies, but individualized outer hair cell damage modeling was less precise. The work demonstrates that biophysically based auditory models can be translated across species, aiding interpretation of animal data for human hearing research and enabling computational studies of hearing loss mechanisms.

Published 2026年5月26日