利用生物資訊重新分析小鼠轉錄組數據集揭示噪音加速耳蝸老化中的SASP及MAPK/NF-κB訊號途徑

// Bioinformatics Re-analysis of murine transcriptomic datasets identifies SASP and MAPK/NF-κB signaling pathways in noise-accelerated cochlear aging

本研究分析小鼠耳蝸基因表現，探討噪音暴露如何加速年齡相關聽力損失｜發現14個關鍵基因涉及噪音反應與老化，相關訊號路徑包括MAPK、NF-κB、JAK-STAT及IL-18｜研究指出發炎、細胞週期停滯、細胞外基質改變與脂質過氧化是噪音加速耳蝸老化的重要機制。

// This study investigated how noise exposure accelerates age-related hearing loss by analyzing mouse cochlear gene expression data. Researchers identified 14 key genes linked to both noise response and aging, with related pathways including MAPK, NF-κB, JAK-STAT, and IL-18 signaling. They developed a classification model based on these genes and found their relevance in cochlear injury and auditory tissue. The findings suggest inflammation, cell cycle arrest, extracellular matrix changes, and lipid peroxidation contribute to noise-accelerated cochlear aging.

Published 2026年5月25日