轉動鼠突變體的聽力損失無法透過激活Whrn基因逆轉

// Hearing loss in a whirlin mouse mutant is not reversed by activating the Whrn gene

本研究利用基因改造小鼠模型探討Whrn基因突變導致的聽力損失能否逆轉｜透過他莫昔芬誘導的Flp重組酶重新啟動Whrn基因表現，但未見聽力或毛細胞立體纖毛結構改善｜結果顯示此類聽力障礙因發育缺陷不可逆，後期基因激活難以恢復聽力，對Whrn相關耳聾的治療策略有重要啟示。

// This study investigated whether hearing loss caused by Whrn gene mutations can be reversed after onset using a genetic mouse model. Researchers used tamoxifen-inducible Flp recombinase to reactivate Whrn expression after hearing loss had begun. Reactivation did not improve hearing or restore hair cell stereocilia structure, indicating that hearing rescue is difficult due to irreversible developmental defects. The findings suggest that Whrn-related deafness is unlikely to be reversed by post-onset gene activation.

Published 2026年5月29日