朗格漢斯細胞組織細胞增生症的常見耳鼻喉臨床表現與症狀及兒童治療方案評估：系統性回顧與統合分析

// Common Otolaryngologic Clinical Manifestations and Symptoms of Langerhans Cell Histiocytosis and Evaluation of Treatment Regimens in Pediatric Patients: A Systematic Review and Meta-Analysis

本系統性回顧分析885例兒童朗格漢斯細胞組織球增生症（LCH），聚焦頭頸部症狀與治療成效｜顱骨及顳骨病變最常見，持續性的耳朵流膿易誤診為慢性感染｜全身性化療為主要治療，約55%病患達到緩解，但復發及死亡率仍顯著｜強調加強診斷精準度與優化治療策略的重要性。

// This systematic review analyzed 885 pediatric Langerhans Cell Histiocytosis (LCH) cases involving the head and neck to characterize otolaryngologic symptoms and treatment outcomes. Skull and temporal bone lesions were most common, with persistent ear discharge often mimicking chronic infections. Systemic chemotherapy was the main treatment, achieving remission in about 55% of cases, but recurrence and mortality rates remained notable. The study emphasizes the need for careful diagnosis and improved treatment strategies for pediatric LCH.

Published 2026年5月29日