腺扁桃體切除術後高風險阻塞性呼吸暫停兒童之術後併發症中介效應

// Mediating effects of postoperative complications in children with high-risk obstructive apnea following adenotonsillectomy

本研究探討阻塞性睡眠呼吸中止症（OSA）嚴重度如何引發高風險兒童扁桃體切除術後併發症｜對307名患者進行因果中介分析，發現最低血氧飽和度、最高二氧化碳濃度及氧飽和度低於90%的時間為關鍵中介指標｜發現低氧飽和時間超越傳統OSA嚴重度評分，為重要併發症預警指標，但結果對未測量混雜因素敏感，需謹慎解讀。

// This study examined how obstructive sleep apnea (OSA) severity leads to postoperative complications in high-risk pediatric patients undergoing adenotonsillectomy. Using causal mediation analysis on 307 patients, it identified oxygen nadir, maximum CO2, and time with oxygen saturation below 90% as key mediators of complications like ICU intervention and prolonged hospitalization. The novel finding is that time with low oxygen saturation is an important marker beyond traditional OSA severity scores. However, these mediation effects are sensitive to unmeasured confounding, so results should be interpreted cautiously.

Published 2026年6月4日