染色質與基因組不穩定性在耳蝸中對年齡相關性聽力損失的影響：體外與體內模型的見解

// Chromatin and genomic instability in the cochlea contributing to age-related hearing loss: Insights from in vitro and in vivo models

本研究聚焦於老年性聽力損失（ARHL）之細胞與分子機制｜利用轉基因鼠與單細胞RNA定序，揭示耳蝸外毛細胞DNA損傷、染色質狀態異常及端粒縮短｜關鍵變化包括DNA斷裂、異染色質流失與ATRX基因表達改變，指示基因組不穩定為聽力衰退核心，並提供ARHL治療潛在基因標的。

// This study investigated the cellular and molecular mechanisms of age-related hearing loss (ARHL) in mouse models, focusing on chromatin and genomic instability. Using transgenic mice and single-cell RNA sequencing, the research revealed increased DNA damage, altered chromatin states, and telomere shortening in cochlear cells, particularly outer hair cells (OHCs). Key changes included DNA strand breaks, heterochromatin loss, and altered ATRX gene expression during aging. The findings suggest chromatin and genomic instability are central to cochlear aging and identify potential genetic targets for ARHL treatment.

Published 2026年6月9日