// Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats
本研究利用小分子螢光原位雜交技術，繪製了clarin-1基因在中央聽覺系統中的表現分布｜發現clarin-1 mRNA在大鼠耳蝸核、下丘腦、內側膝狀體及聽覺皮質等多個聽覺腦區均有表達，下丘腦表現量最高，展現區域專一性｜結果顯示clarin-1功能不僅限於毛細胞，也涉及中央聽覺核團，為遺傳性聽力損失和相關治療策略提供重要依據。
// This study aimed to map clarin-1 gene expression in the central auditory system to better understand its role in hereditary hearing loss linked to Usher syndrome type IIIA. Using small molecule fluorescent in situ hybridization (smFISH), clarin-1 mRNA was detected in multiple auditory brain regions of rats, including the cochlear nucleus, inferior colliculus, medial geniculate body, and auditory cortex. The highest expression was found in the inferior colliculus, indicating region-specific variation. These findings suggest clarin-1's role extends beyond hair cells to central auditory nuclei, guiding future research and therapy development.
Published 2026年6月25日
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