順鉑誘導感音神經性聽力損失中 HES1/PI3K/Akt/mTOR 訊號通路的機制研究

// Mechanistic study of HES1/PI3K/Akt/mTOR signaling pathway in cisplatin-induced sensorineural hearing loss

本研究探討HES1/PI3K/AKT/mTOR訊號通路在順鉑誘導聽覺細胞損傷中的作用｜順鉑提升炎症與氧化壓力，敲降HES1則減輕損害｜抑制該通路有助保護細胞，提示其為預防順鉑導致聽力損失的潛在治療靶點。

// This study explored how the HES1/PI3K/AKT/mTOR signaling pathway contributes to cisplatin-induced damage in auditory cells. Cisplatin increased inflammation and oxidative stress, while knocking down HES1 reduced these harmful effects. Activation of the PI3K/AKT/mTOR pathway was essential for cisplatin toxicity, and its inhibition helped protect cells. The findings suggest that targeting this signaling axis could prevent hearing loss caused by cisplatin.

Published 2026年6月25日