噪音誘發性聽力損失的多基因風險評分分析：一項整合橫斷面與縱向研究

// Polygenic risk score analysis of noise-induced hearing loss: An integrated cross-sectional and longitudinal study

本研究分析7個基因變異組成的多基因風險分數（PRS）與噪音誘發聽力損失（NIHL）之間的關聯｜超過5800名工人數據顯示，高PRS者NIHL風險與聽力惡化明顯增加，尤以累積噪音暴露者為甚｜結果證實遺傳因素與噪音暴露及年齡交互影響NIHL風險，PRS有助預測個體脆弱性。

// This study examined whether a polygenic risk score (PRS) based on seven genetic variants is linked to susceptibility to noise-induced hearing loss (NIHL). Using data from over 5,800 workers, high PRS was associated with increased risk of NIHL and hearing deterioration, especially when combined with cumulative noise exposure. The findings indicate that genetic factors influence NIHL risk and interact with noise exposure and age. Thus, PRS can help predict individual vulnerability to NIHL.

Published 2026年6月26日