// Repopulating microglia recapitulate developmental characteristics during a period of auditory circuit recovery
本研究探討微膠細胞在聽覺腦幹迴路發育中的角色｜透過CX3CR1+/EGFP小鼠比較微膠細胞於正常發育及耗竭後重建期間的形態與吞噬活性｜結果顯示重建中的微膠細胞重新展現有助於突觸精修的發育特徵，超越一般發育時窗｜顯示微膠細胞能恢復關鍵發育功能，支持神經迴路組裝，具重要應用價值。
// This study investigates the role of microglia in developing auditory brainstem circuits, focusing on their morphology and phagocytic activity during normal development and repopulation after depletion. Using CX3CR1+/EGFP mice, the researchers compared microglial features such as surface area, volume, branching, and lysosomes in both conditions. They found that repopulating microglia regain developmental characteristics associated with synaptic refinement, even after the normal developmental period. This indicates microglia can resume critical developmental functions to support circuit assembly beyond typical timeframes.
Published 2026年6月28日
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