Slc16a5 (MCT6) 基因剔除引起小鼠聽覺功能、毛細胞存活率及耳蝸轉錄體程序之性別依賴性變化

// Slc16a5 (MCT6) knockout induces sex-dependent changes in auditory function, hair cell viability and cochlear transcriptomic programs in the mouse

本研究利用Mct6缺失小鼠探討單羧酸轉運蛋白6（Mct6）在耳蝸功能中的角色｜發現Mct6對耳蝸抗壓力關鍵，女性小鼠出現早期聽力下降及毛細胞損失，男性則具暫時性聽覺保護｜RNA定序顯示性別差異的雌激素反應基因及壓力反應變化，凸顯Mct6透過不同分子機制維持耳蝸穩態的重要性

// This study examined the role of monocarboxylate transporter 6 (Mct6) in cochlear function using Mct6-deficient mice. Researchers found Mct6 is crucial for cochlear stress resistance, with females showing early hearing loss and increased hair cell loss, while males displayed temporary auditory protection. RNA sequencing revealed sex-dependent changes in estrogen-responsive genes and stress responses. The findings highlight Mct6’s importance in maintaining cochlear homeostasis via distinct molecular mechanisms in males and females.

Published 2026年6月27日