普通絨猴耳蝸中PROX1、GLAST、GFAP及PLP1的特徵表現模式

// Characteristic expression patterns of PROX1, GLAST, GFAP, and PLP1 in the cochlea of the common marmoset

本研究分析新世界猴耳蝸支持細胞中PROX1、SLC1A3、GFAP及PLP1基因表現｜發現PROX1與SLC1A3在靈長類與囓齒類動物間表現保守，GFAP受限，PLP1則在人類近親的新世界猴中缺失｜結果指出，囓齒類動物的基因操作方法不適用於靈長類，強調需開發專屬靈長類的遺傳工具以推動聽覺研究與治療。

// This study examined gene expression of cochlear supporting cells in the common marmoset, a primate model, focusing on PROX1, SLC1A3, GFAP, and PLP1 markers. PROX1 and SLC1A3 showed conserved expression patterns between rodents and primates, while GFAP was more limited and PLP1 was absent in marmosets. These differences suggest rodent-based gene manipulation methods may not directly apply to primates. The findings emphasize the need for primate-specific genetic tools to better study cochlear biology and develop therapies for human hearing loss.

Published 2026年6月29日