突觸病變性噪音後的耳蝸老化：毛細胞喪失與軸突退化中的年齡-噪音交互作用

// Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration

本研究探討小鼠噪音引起的突觸損失後，聽神經纖維（ANF）周邊軸突的長期退化｜發現突觸立即減少50%，恢復有限；軸突損失較晚且兩年後仍較輕微｜多數ANF軸突存活，維持訊號產生，顯示治療介入仍有長期機會｜老化帶來輕微病理變化，但未顯著加劇噪音傷害。

// This study examined long-term degeneration of auditory-nerve fiber (ANF) peripheral axons after noise-induced synapse loss in mice. Using immunostaining and machine learning, they found immediate 50% synapse loss with minimal recovery, while axon loss occurred later and remained less severe even after two years. Despite synaptic damage, most ANF axons survived, maintaining spike generators and highlighting a prolonged opportunity for therapeutic intervention. Aging caused additional subtle pathologies but did not strongly worsen noise-induced damage.

Published 2026年6月30日