從聽力圖估計毛細胞損失

// Estimation of hair cell loss from audiograms

本研究建立生物物理模型，將聽力閾值與耳蝸內外毛細胞存活率連結｜利用人類屍體數據，模型能準確預測低頻聽力表現｜發現外毛細胞損傷主要影響高頻聽力與耳蝸機制，聽力圖對整體功能衰退較敏感｜此架構量化聽力圖與細胞損傷關係，但單憑閾值難以精確診斷耳蝸病變。

// This study presents a biophysically-based model linking audiometric thresholds to inner and outer hair cell survival in the cochlea. Using postmortem human data, the model predicts audiograms from hair-cell distribution, with better accuracy at low frequencies. The findings show that outer hair cell dysfunction mainly affects high-frequency hearing and cochlear mechanics, while audiograms are more sensitive to overall dysfunction than detailed spatial patterns. The framework quantitatively connects audiograms to cellular damage but reveals limits in diagnosing precise cochlear pathology from threshold data alone.

Published 2026年7月2日