TGF-β訊號調控嚴重受傷成年鼠前庭器扁平上皮形成之上皮-間質轉換

// TGF-β signaling regulates flat epithelium formation in severely injured adult mouse utricle through epithelial-mesenchymal transition

本研究探討TGF-β訊號在前庭感覺上皮嚴重受損後形成扁平上皮（FE）的角色｜發現TGF-β在損傷後迅速活化，調控上皮-間質轉換（EMT）標記物，影響修復過程｜增強TGF-β可加速傷口癒合與EMT，抑制則延遲癒合，顯示其在FE形成及損傷修復中具關鍵調控作用。

// This study investigates the role of TGF-β signaling in forming a flat epithelium (FE) after severe injury to vestibular sensory epithelium. Using in vivo and in vitro methods, the researchers found that TGF-β signaling is rapidly activated post-injury and modulates epithelial-mesenchymal transition (EMT) markers during FE formation. Enhancing TGF-β accelerates wound closure and EMT, while inhibiting it delays healing and reduces mesenchymal marker expression. Thus, TGF-β signaling critically regulates FE formation by controlling EMT processes after injury.

Published 2026年7月3日