聽覺毛細胞的膜支架構造 — 分子間的鋼索行走實現側壁的剛性與柔韌性

// Membrane scaffolding in auditory hair cells - a molecular tightrope walk enables lateral wall stiffness and flexibility

本評論探討哺乳動物耳蝸外毛細胞（OHCs）如何透過電動性加強聲音振幅｜重點解析由膜蛋白prestin驅動的運動機制及其三層結構支持快速機械變化｜強調光鏡下仍未明確的光譜蛋白亞型與膜-細胞骨架連接器，以及膜下腔體的功能，指出未來研究關鍵與應用價值。

// This review examines how outer hair cells (OHCs) in the mammalian cochlea enable sound amplification through electromotility, driven by the motor protein prestin in the plasma membrane. It highlights the specialized trilaminate lateral wall structure—plasma membrane, actin/spectrin cortical lattice, and subsurface cisternae—that supports rapid mechanical changes. Key unresolved issues include the specific spectrin isoforms, membrane-cytoskeleton connectors, and the role of subsurface cisternae. The paper outlines current understanding and critical gaps for advancing knowledge of cochlear amplification mechanisms.

Published 2026年7月3日