比對睡鼠因突觸病變噪音暴露與卡鉑誘發之內毛細胞功能障礙的生理特徵

// Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas

本研究使用無創檢測比較兔耳模型中卡鉑（CA）與噪音短暫閾值升高（TTS）引起的耳蝸突觸病變（CS）與內毛細胞（IHC）損傷｜兩組聽力閾值無明顯變化，但在包絡追蹤反應（EFR）、腦幹聽覺反應（ABR）波5/1比值與寬頻中耳肌反射（WB-MEMR）呈現顯著差異｜結果顯示EFR峰值特徵、ABR比值和WB-MEMR綜合評估，有助區分內毛細胞功能障礙與突觸病變，揭示兩種隱性聽力損失類型。

// This study compared cochlear synaptopathy (CS) and inner hair cell (IHC) damage using non-invasive assays in chinchilla models exposed to carboplatin (CA) and noise-induced temporary threshold shift (TTS). Both groups showed unchanged hearing thresholds, but distinct differences emerged in Envelope Following Responses (EFRs), Auditory Brainstem Response (ABR) Wave 5/1 ratios, and Wideband Middle-Ear Muscle Reflexes (WB-MEMRs). TTS exposure caused more pronounced WB-MEMR changes and less elevation in ABR ratios, while differing DPOAE patterns indicated varied outer hair cell effects. The findings suggest combined measures of EFR "peakiness," ABR ratios, and WB-MEMR can differentiate IHC dysfunction and CS as distinct hidden hearing loss types.

Published 2026年7月13日