錐形窗超聲刺激直接在小鼠聽覺皮層引發特徵性分層反應，同時最小化外周聽覺反應

// Tapered-window ultrasound stimulation directly evokes characteristic laminar responses in the mouse auditory cortex while minimizing peripheral auditory responses

本研究開發出具漸進式包絡線的經顱超聲刺激法，直接激活小鼠聽覺皮層（AC）｜實驗中逐漸減弱的超聲刺激降低了腦幹的周邊聽覺干擾，但仍有效誘發AC反應｜在去耳小鼠中確認此技術能精準作用於聽覺皮層，提升超聲神經調控的準確性與應用潛力。

// This study developed a transcranial ultrasound stimulation (TUS) method with tapered temporal envelopes to directly activate the mouse auditory cortex (AC) while minimizing peripheral auditory responses. They recorded brainstem and cortical activity in normal and deafened mice, showing that gradual tapering of ultrasound stimuli reduced peripheral auditory artifacts but still evoked AC responses. In deafened mice, these tapered stimuli directly stimulated the AC, confirming minimal peripheral involvement. This method enables more precise ultrasound neuromodulation targeting cortical auditory circuits.

Published 2026年7月20日