結合基礎成纖維細胞生長因子與明膠海綿療法促進小鼠爆炸傷後接近正常的鼓膜再生

// Combined Basic Fibroblast Growth Factor and Gelatin Sponge Therapy Achieves Near-Normal Tympanic Membrane Regeneration After Blast Injury in Mice

本研究探討將基礎成纖維細胞生長因子（bFGF）與明膠海綿支架結合（bFGF+gel）對小鼠爆炸性鼓膜穿孔的癒合效果｜56天內bFGF+gel使膜厚度接近正常且膠原結構組織良好，優於單獨使用bFGF或明膠｜爆炸傷各組14天內閉合穿孔，但聽力均受損，無治療差異，顯示結合療法更具結構修復潛力，適合進一步臨床研究。

// This study tested whether combining basic fibroblast growth factor (bFGF) with a gelatin sponge scaffold (bFGF+gel) improves healing of blast-induced tympanic membrane perforations in mice. The bFGF+gel treatment led to near-normal membrane thickness and organized collagen structure by day 56, surpassing effects of bFGF or gelatin alone. All blast-exposed groups closed perforations by day 14 but showed hearing deficits without differences between treatments. The findings suggest combined growth factor and scaffold therapy may better restore membrane structure after blast injury, warranting further clinical studies.

Published 2026年7月22日