// Three-Dimensional Histopathologic Correlates of Cochlear Hypoplasia Type II Versus Incomplete Partition Type II
本研究比較了耳蝸發育不全型II（CH-II）與不完整分隔型II（IP-II）內耳畸形｜分析聽神經中樞與耳蝸面積比及耳蝸鱗片間角度，發現兩者均較正常值縮小且角度變平，但CH-II的螺旋神經節細胞數顯著低於IP-II｜結果強調正確區分CH-II與IP-II對人工耳蝸植入適應症及預後評估具關鍵意義，並提出基於組織學的預測算法協助鑑別。
// This study compares cochlear hypoplasia type-II (CH-II) and incomplete partition type-II (IP-II) inner ear malformations by analyzing modiolar: cochlear area ratios and interscalar ridge angles from histologic and 3D reconstructions. Both CH-II and IP-II showed smaller modiolar: cochlear area ratios and flattened interscalar ridge angles compared to controls, but CH-II had significantly lower spiral ganglion neuron (SGN) counts than IP-II. The findings suggest that precise radiologic differentiation between CH-II and IP-II is critical for cochlear implant candidacy and prognosis. A histology-based predictive algorithm is proposed to aid in distinguishing these malformations.
Published 2026年7月27日
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