Wbp2基因活化及修飾基因Cdh23^ahl對Wbp2小鼠突變體漸進性聽力喪失的影響

// Effects of Wbp2 gene activation and the modifier Cdh23^ahl on progressive hearing loss in Wbp2 mouse mutants

本研究探討啟動Wbp2基因是否能預防或逆轉Wbp2突變小鼠的聽力喪失｜結果顯示，在聽力下降前後激活Wbp2均無法阻止或恢復聽力｜但矯正常見遺傳修飾子Cdh23ahl等位基因，能完全恢復突變小鼠的正常聽力｜強調早期突觸聽力缺陷治療的挑戰以及遺傳背景對聽力功能的重要影響。

// This study investigated whether activating the Wbp2 gene could prevent or reverse hearing loss caused by synaptic defects in Wbp2 mutant mice. Activating Wbp2 before or after hearing loss onset did not stop or reverse auditory decline. However, correcting a common genetic modifier, the Cdh23ahl allele, fully restored normal hearing in mutant mice. These results emphasize the challenge of treating early synaptic hearing defects and the crucial role of genetic background in auditory function.

Published 2026年7月30日