// Neurovascular-Immune Biomarkers in Ménière Disease: Insights From High-Throughput Proteomics
本研究透過大規模蛋白質體學分析1037種血清蛋白，識別美尼爾氏症（MD）系統性生物標記｜發現神經內分泌、組織重塑及壓力適應蛋白顯著上調，表皮維護與免疫因子則下調，顯示組織修復與免疫監控失衡｜結果支持MD為神經血管免疫疾病，提供潛在診斷及患者分層的蛋白質標記框架。
// This study aimed to identify systemic biomarkers for Ménière disease (MD) by profiling 1037 serum proteins in patients versus controls using large-scale proteomics. Key findings revealed distinct upregulation of neuroendocrine, tissue-remodeling, and stress-adaptation proteins, alongside downregulation of epithelial maintenance and immune factors, indicating dysregulated tissue repair and immune surveillance. The results suggest MD is a neurovascular-immune disorder involving compensatory pathways rather than just inner ear hydrops. The identified proteomic signature offers a promising biomarker framework for diagnosis and patient stratification.
Published 2026年8月12日
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