耳蝸微膠細胞類中前顆粒素表達下降加速年齡相關性聽力喪失進程

// The decline of progranulin expression in cochlear Microglia-Like Cells accelerates the progression of age-related hearing loss

本研究探討耳蝸微膠質樣細胞（MLCs）在年齡相關性聽力損失（ARHL）中的作用｜發現老年小鼠耳蝸中MLCs高度活化，去除這些細胞可減緩聽力損失速度｜利用單細胞轉錄組和功能測試顯示，增加MLCs中前程蛋白（GRN）可減少氧化壓力損傷，具保護耳蝸細胞潛力，為延緩ARHL提供新策略。

// This study investigates the role of cochlear microglia-like cells (MLCs) in age-related hearing loss (ARHL). The researchers found that MLCs are highly activated in aged mice cochleae, and depleting these cells slows ARHL progression. Using single-cell transcriptomics and functional tests, they showed that increasing progranulin (GRN) in MLCs reduces oxidative stress damage in the aging cochlea. Targeting GRN signaling in MLCs may therefore delay ARHL by protecting cochlear cells from oxidative stress.

Published 2026年8月12日