主觀耳鳴存在及臨床負擔之生物標記：系統性綜述

// Biomarkers of Subjective Tinnitus Presence and Clinical Burden: A Systematic Review

本系統性綜述分析69項研究，評估客觀生物指標在診斷及衡量耳鳴嚴重度的應用｜認知行為指標中特別是注意力調節的腦皮層反應與耳鳴負擔關聯最明顯，具臨床潛力｜分子標記如代謝組學具前景但缺乏重複驗證，神經生理及影像標記有助理解但受限於可重複性與臨床實用性｜目前尚無單一生物標記能獨立診斷耳鳴，需標準化方法與多模態綜合指標。

// This systematic review evaluated objective biomarkers for diagnosing and measuring tinnitus severity from 69 studies across various methods. Cognitive-behavioural measures, especially attention-modulated cortical responses, showed the most consistent link to tinnitus burden and clinical potential. Molecular biomarkers like metabolomics appear promising but lack replication, while neurophysiological and neuroimaging markers aid understanding but face reproducibility and clinical feasibility issues. Overall, no biomarker currently enables standalone tinnitus diagnosis, highlighting the need for standardized methods, larger samples, and multimodal validated panels.

Published 2026年8月18日