七天低壓低氧誘發小鼠基底耳蝸突觸前帶狀結構早期損傷及氧化壓力，細胞明顯喪失前發生

// Seven-day hypobaric hypoxia induces early basal cochlear presynaptic ribbon injury and oxidative stress in mice before overt cellular loss

本研究探討模擬高海拔缺氧7天後小鼠耳蝸的早期變化｜發現高頻聽力下降與突觸前緞帶損傷及氧化壓力增加有關，但毛細胞與螺旋神經節細胞尚未受損｜轉錄組分析揭示突觸和鈣信號相關基因異常，顯示缺氧導致聽力損傷前，先發生突觸損傷與氧化壓力升高。

// This study investigated early cochlear changes in mice after 7 days of simulated high-altitude hypoxia. They found high-frequency hearing loss linked to presynaptic ribbon damage and increased oxidative stress, despite preserved hair and spiral ganglion cells. Transcriptome analysis revealed altered genes related to synaptic and calcium signaling processes. The results suggest early synaptic injury and oxidative stress precede cell loss in hypoxia-induced hearing impairment.

Published 2026年8月19日