電子顯微鏡揭示原發性副甲狀腺功能亢進症高鈣血症小鼠模型中耳石異常

// Electron Microscopy Reveals Abnormal Otoconia in a Hypercalcemic Mouse Model of Primary Hyperparathyroidism

本研究探討慢性高血鈣對小鼠耳石（otoconia）大小與結構的影響｜掃描電子顯微鏡顯示高血鈣轉基因小鼠耳石顯著較小且多出現斷裂｜結果指出鈣質失衡可能導致耳石退化，增強良性陣發性位置性眩暈（BPPV）等前庭疾病風險。

// This study investigated whether chronic hypercalcemia affects otoconia size and structure in mice. Using scanning electron microscopy, otoconia from hypercalcemic transgenic mice were compared to controls and found to be significantly smaller with more fractures. These findings suggest chronic calcium dysregulation may cause otoconial degeneration, potentially contributing to vestibular disorders like BPPV.

Published 2026年8月27日