奧沙利鉑化療誘發的耳蝸突觸病變

// Oxaliplatin-chemotherapy induced cochlear synaptopathy

本研究探討奧沙利鉑對小鼠聽力及耳蝸結構的影響｜結果顯示雖然聽閾和毛細胞無明顯損傷，但神經突觸流失及神經功能降低，顯示隱性神經耳毒性｜此發現挑戰奧沙利鉑無耳毒性的認知，建議需敏感聽力檢測以早期發現神經損傷，有助臨床監測聽力缺損。

// This study investigated whether oxaliplatin causes hearing damage in mice by assessing auditory function and cochlear structure after treatment. Although oxaliplatin did not affect hearing thresholds or hair cell integrity, it caused significant neural impairments, including loss of synapses and reduced nerve function, indicating hidden neuro-ototoxicity. These findings challenge the belief that oxaliplatin is non-ototoxic and suggest that sensitive auditory measures beyond hearing thresholds are needed to detect early neural damage. Developing clinical tests targeting these subclinical changes could improve monitoring of oxaliplatin-induced hearing deficits.

Published 2026年8月28日