耳鳴相關情緒困擾是否具有特徵性 EEG 標誌？來自頻譜參數化與腦源層級功能連結性的證據

// Are there distinctive EEG Signatures of tinnitus-related emotional distress? Evidence from spectral parameterization and source-level functional connectivity

靜息態EEG分析(PLV等)顯示耳鳴患者非週期指數↑（示皮質興奮—抑制失衡）及顳區α峰頻↓（聽覺振盪變慢）｜網路分析見聽覺—頂葉同步↑、聽覺與ACC/PFC連結↓，指向與耳鳴情緒困擾相關聽覺網路異常，提示神經調控治療靶點，與抑鬱症模式略異。

// This study used resting-state EEG with spectral parameterization and source-level phase-locking value (PLV) to identify neural oscillatory and connectivity features linked to subjective tinnitus and its emotional distress. Compared with controls, tinnitus patients had a higher aperiodic exponent—suggesting altered cortical excitation–inhibition balance—and a reduced alpha peak frequency in temporal regions, indicating slowing of auditory cortical oscillations. Connectivity analysis showed increased synchronization within and between auditory and parietal regions, but decreased connectivity between auditory regions and the anterior cingulate and prefrontal cortex. These altered oscillatory and connectivity patterns point to abnormal auditory-network synchronization tied to tinnitus-related distress and may inform future neuromodulatory interventions, differing somewhat from patterns seen in primary depressive disorders.

Published 2026年9月13日