海馬與杏仁核優先投射至聽覺皮質的SST陽性抑制性中間神經元

// Hippocampal and amygdalar structures preferentially target somatostatin-expressing interneurons in the auditory cortex

以狂犬病病毒逆行單突觸追蹤，量化小鼠聽覺皮層SST+（somatostatin陽性抑制性中間神經元）與整體神經元之長程輸入｜兩者主要來自同側聽覺皮層、內側膝狀體及其他感覺區，但SST+自海馬與杏仁核等邊緣系統輸入顯著較多，顯示其將情緒與記憶訊息引入聽覺皮層，可能影響聽覺學習與狀態依賴性閘控，具機制與應用研究價值。

// They mapped long-range inputs to somatostatin-expressing (SST+) interneurons in mouse auditory cortex to compare them with the overall cortical input network. Using rabies-based retrograde monosynaptic tracing, they quantified presynaptic sources to SST+ cells versus general auditory neurons. While most inputs came from ipsilateral auditory cortex, medial geniculate body, and other sensory areas for both groups, SST+ interneurons received significantly more inputs from limbic regions (hippocampus and amygdala). This preferential targeting suggests SST+ cells link emotion and memory centers to auditory cortex, potentially shaping auditory learning and state-dependent gating.

Published 2026年9月10日