水楊酸鹽對沙鼠耳蝸第二轉柯蒂氏器振動之影響

// Effects of salicylate on organ-of-Corti vibrations in the second turn of the gerbil cochlea

研究在麻醉沙鼠耳圓窗局部施用水楊酸，並以光學相干斷層掃描記錄DPOAE與柯蒂氏器（聲蝸感覺受器）振動｜水楊酸引起DPOAE與耳內振幅隨時間與頻率下降，於低強度刺激、接近最佳頻率時減幅最大，顯示外毛細胞（OHC）介導的耳蝸增益喪失｜相位關係大致維持、基底膜與OHC區域振動同步減弱，指出OHC主動力跨局部結構作用，且DPOAE可作為頻率特異性之耳蝸放大指標

// To determine how suppressing outer hair cell (OHC) function alters intracochlear mechanics, we applied salicylate to the round window of anesthetized gerbils and recorded distortion-product otoacoustic emissions (DPOAEs) and organ of Corti vibrations in the second turn with optical coherence tomography. Salicylate caused time- and frequency-dependent reductions in DPOAEs and a broad decrease in intracochlear vibration amplitudes, largest for low-level stimuli near the best frequency, consistent with loss of OHC-mediated cochlear gain. Phase relationships were largely preserved, indicating attenuation of active feedback without major changes in mechanical coupling, and similar reductions in basilar membrane and OHC-region motion show OHC forces act across the local partition. DPOAE reductions closely tracked local intracochlear gain loss near the best frequency, supporting their use as frequency-specific indicators of cochlear amplification.

Published 2026年9月10日