環境噪音暴露對耳蝸反應的數學與計算建模：初步多尺度計算研究

// Mathematical and computational modelling of cochlear responses to environmental noise exposure: A preliminary multiscale computational study

建立多尺度被動耳蝸計算框架，模擬30–85 dB SPL對力學與神經活動的映射｜30→85 dB輸入使基底膜位移約增加55 dB，並重現音位中心頻(CF)與Q10模式，提出環境聽覺風險指數｜此為無外毛細胞(OHC)放大之初步模型，需納入非線性OHC、低頻延伸與實驗驗證後方可用於預測或臨床評估

// This study organized established cochlear models into a multiscale computational framework to test how environmental sound levels (30–85 dB SPL) map onto passive cochlear mechanics and simulated neural activity. It combined three modules: a 1D transmission-line cochlear model, a 3D FDTD fluid–basilar-membrane model, and a perceptual post-processing stage (ERB filtering, inner-hair-cell transduction, stochastic auditory-nerve firing), all run under passive linear assumptions (no outer-hair-cell amplification). Higher input levels increased basilar-membrane displacement, fluid pressure, and simulated neural activity/burstiness (the 1D model showed ≈55 dB increase in BM displacement from 30 to 85 dB with proportional scaling and preserved frequency–position geometry), and the framework produced tonotopic CF and Q10 patterns within the simulated range and an exploratory Environmental Auditory Risk Index. The authors emphasize this is a controlled, preliminary passive model—not evidence of active amplification or clinical risk—and requires nonlinear OHC mechanics, lower-frequency extension, sensitivity analysis, and experimental validation before predictive use.

Published 2026年9月2日