碳酸化液體對帕金森氏症患者吞嚥安全性的影響（DYSparkLE）：一項前瞻性受試者內、重複測量之觀察性研究

// The Effect of Carbonated Liquid on Swallowing Safety of People with Parkinson Disease (DYSparkLE): A Prospective Within-Subject, Repeated-Measures Observational Study

83名帕金森病患者以FEES檢測含氣液(CL)與非含氣液，90 mL的氣道入侵深度(DAI)為主要終點｜含氣液顯著降低氣道入侵風險並減少不安全吞嚥；自覺吞嚥症狀較少者獲益較多，喉部感覺受損者效益較小｜顯示CL可作個別化評估與吞嚥復健之輔助策略，但仍需進一步探討其作用機制。

// This study tested whether drinking carbonated liquid (CL) improves swallowing safety in 83 people with Parkinson disease using flexible endoscopic evaluation of swallowing (FEES), comparing 5 and 90 mL non-carbonated and carbonated liquids with depth of airway invasion (DAI) at 90 mL as the primary outcome. Multilevel logistic regression showed CL significantly reduced the odds of airway invasion versus non-carbonated liquid. Exploratory subgroup analysis indicated greater benefit in patients reporting fewer dysphagia symptoms and less benefit when laryngeal sensitivity was impaired. Overall, CL produced significantly fewer unsafe swallows and could be useful in individualized assessment and rehabilitation, warranting further mechanistic study.

Published 2026年9月11日