// Monitoring Hearing Function in Patients With Sporadic Vestibular Schwannoma: A Feasibility Study to Inform a Future Randomized Controlled Trial
非隨機單中心可行性研究：招募44人、31人入組（22 WW觀察、9 SRS），25人完成（80%），平均評估1小時42分｜受損耳4F‑PTA：WW 42±14 dB HL vs SRS 55±9.4 dB；antiphasic DiN‑SRT50：WW −14.2±4.1 vs SRS −11.6±1.9 dB SNR，兩者高度相關（P<0.001）｜結論：招募、留存與測試完成度足以推進決定性RCT，並提供樣本數估算所需變異數。
// This feasibility study tested whether a definitive RCT comparing upfront stereotactic radiosurgery (SRS) versus watch‑and‑wait (WW) for hearing preservation in vestibular schwannoma is practical, using a nonrandomized prospective single‑centre design with audiometric and patient‑reported measures. Of 44 recruited, 31 (22 WW, 9 SRS) met criteria and 25 (80%) completed all tests; mean assessment time was 1 h 42 min. Mean 4‑frequency PTA in affected ears was 42 ± 14 dB HL (WW) versus 55 ± 9.4 dB HL (SRS), antiphasic DiN‑SRT50 was −14.2 ± 4.1 dB SNR (WW) versus −11.6 ± 1.9 dB SNR (SRS), and 4FAPTA correlated with antiphasic DiN‑SRT50 (P < 0.001). The study concludes recruitment, retention, and test completion are sufficient to proceed to an RCT and provides variance estimates for sample‑size calculation.
Published 2026年9月11日
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