早產嬰兒支氣管肺發育不良、足月當齡時胼胝體微結構與2歲時神經發展之間的關係

// Relationship Between Bronchopulmonary Dysplasia, Corpus Callosum Microstructure at Term-Equivalent Age, and Neurodevelopment at Age 2 Years in Infants Born Preterm

392位≤32週早產兒前瞻性研究，足月MRI胼胝體追蹤、2歲Bayley‑III評估｜BPD嚴重度與胼胝體後中段/峽部FA(各向異性)下降及三項發展分數下降相關｜胼胝體僅部分中介認知（後中段解釋12.7%），BPD仍有直接影響，應早期介入改善預後

// We prospectively studied 392 infants born ≤32 weeks GA who had diffusion MRI at term-corrected age with automated tractography of the corpus callosum and Bayley-III testing at 2 years, using multivariable regression and mediation analyses to link bronchopulmonary dysplasia (BPD) severity, callosal fractional anisotropy (FA), and development. Higher BPD grades were associated with lower FA in the posterior midbody and isthmus of the corpus callosum. Greater BPD severity was also linked to lower Bayley-III cognitive, language, and motor scores. Callosal microstructure modestly mediated the cognitive association (posterior midbody explained 12.7% of the effect), but most mediation effects were small/non-significant and a direct adverse effect of BPD persisted.

Published 2026年9月3日