// Juvenile recurrent parotitis and risk of autoimmune disease: A 30-year nationwide cohort study
幼年復發性腮腺炎(JRP)與未來自體免疫疾病風險增加｜累積風險4.73%對3.02%，總體HR=1.71；Sjögren氏症HR=28.16｜女性與青少年關聯更強，提示JRP可作為自體免疫疾病早期警訊，具臨床追蹤與預防意義。
// This study tested whether juvenile recurrent parotitis (JRP) is associated with later autoimmune disease and whether associations differ by sex and age. Using a Danish nationwide cohort (1994–2024) of 2,915 JRP cases and 29,140 matched controls, cumulative risks were estimated with the Aalen–Johansen estimator and hazard ratios with Cox regression across ten autoimmune groups. JRP was linked to higher autoimmune risk (cumulative 4.73% vs 3.02%; HR 1.71), notably Sjögren’s disease (HR 28.16), connective tissue diseases (HR 3.69), and gastrointestinal diseases (HR 1.55). Associations were stronger in females and adolescents, suggesting JRP may signal increased risk or an early indicator of autoimmune disease.
Published 2026年9月7日
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