以細胞療法提升聽覺神經功能：現況、手術方式與潛在適應對象

// Boosting auditory nerve function with cell therapy - status, surgical approach and potential candidates

回顧顯示SGN與人工耳蝸成效關聯有限，神經功能常勝過絕對神經數量｜屍體與前臨床證實手術輸送ONP（耳源性前驅細胞）可行，但電生理屬間接檢測，難以個體識別SGN退化｜ONP具潛力但仍研究性，需嚴謹分層與驗證，並證實長期安全與功能整合

// This review examines whether spiral ganglion neuron (SGN) integrity predicts cochlear implant outcomes and assesses the feasibility of otic neural progenitor (ONP) cell therapy by surveying electrophysiological diagnostics and surgical delivery approaches. Cadaveric and preclinical studies show surgical delivery is technically feasible, and the evidence suggests neural function rather than absolute SGN counts often limits implant benefit. Current electrophysiological tools are indirect and cannot identify SGN degeneration in individuals with the specificity required for trial enrollment. ONP therapy is promising but still investigational and will require rigorous patient stratification, validated diagnostic and outcome measures, and demonstration of long-term safety, cell survival, differentiation, connectivity, and functional integration with implants.

Published 2026年9月19日