聲學變化複合（Acoustic Change Complex, ACC）聽覺誘發電位的神經起源：聽覺皮質的拓樸圖與訊源定位

// Neural origins of the acoustic change complex auditory evoked potential: Topographical maps and source localization in the auditory cortex

18名正常聽力者以128通道EEG記錄1 kHz、10%頻變刺激，LCMV定位來源｜ACC（聲學變化複合體，反映皮質對頻率變化）呈P1–N1–P2且頭皮地圖似起始響應；源於雙側聽覺皮質N1峰，與起始反應共享產生器，可作為評估頻率處理之指標。

// The study aimed to map the acoustic change complex (ACC) across the scalp and localize its neural generators using high-density EEG. Eighteen normal-hearing adults were recorded with 128-channel EEG during a 1 kHz tone containing a 10% frequency change, and sources were estimated with MNE-Python using LCMV beamforming. The ACC produced classic P1–N1–P2 waveforms and scalp topographies resembling sound-onset responses. Source localization showed bilateral N1 peaks in auditory cortex, indicating the ACC arises bilaterally in auditory cortex and likely shares generators with the onset response.

Published 2026年9月16日