氨基糖苷類藥物損傷（而非遺傳性毛細胞消融）偏好性地減少 Ic 型螺旋神經節神經元

// Aminoglycoside injury, but not genetic hair cell ablation, preferentially reduces Type Ic spiral ganglion neurons

在三種成年小鼠耳蝸模型（Pou4f3‑DTR、局部/全身胺基糖苷）檢視螺旋神經節神經元(SGN)亞型退化｜DTR導致Type I減少但Type Ic（低自發放電率）比例不變，胺基糖苷則Type I減少且Type Ic比例下降｜顯示Type Ic脆弱性取決於損傷類型，提示需依病因客製化聽力保護與治療策略。

// The study tested whether low-spontaneous-rate (Type Ic) spiral ganglion neurons (SGNs) are selectively vulnerable across different cochlear injuries by comparing subtype-specific degeneration in three adult mouse models: Pou4f3-DTR hair-cell ablation and local and acute systemic aminoglycoside exposure. In the DTR model Type I SGNs degenerated without a change in the proportion of Type Ic cells, whereas both aminoglycoside models caused Type I loss and a decreased proportion of Type Ic SGNs. These results show SGN subtype vulnerability differs by injury type, so Type Ic susceptibility depends on the nature of cochlear injury.

Published 2026年9月16日