以目擊呼吸暫停為特徵之臨床定義兒童睡眠相關呼吸障礙表型的單核球對高密度脂蛋白膽固醇比值

// Monocyte-to-HDL cholesterol ratio in a clinically defined pediatric sleep-related breathing disorder phenotype characterized by witnessed apnea

74例SRBD(目擊呼吸暫停)兒童與70例對照比單核球/HDL比值(MHR)｜SRBD組MHR中位數13.84比10.15，調整後OR1.315/單位(p<0.001)，AUC0.563→0.777(校正0.762)｜MHR僅供研究參考

// We evaluated whether the monocyte-to-HDL cholesterol ratio (MHR) differs in children with a clinically defined sleep-related breathing disorder (witnessed apnea/respiratory pauses) versus controls. In a retrospective case-control study of 74 cases and 70 controls, MHR was compared using age- and sex-adjusted logistic regression, ROC analysis, and bootstrap internal validation. MHR was significantly higher in the SRBD group (median 13.84 vs 10.15; adjusted OR 1.315 per unit, p < 0.001) and adding MHR raised AUC from 0.563 to 0.777 (optimism-corrected AUC 0.762). MHR showed the best single-marker performance but was not conclusively superior to monocyte or HDL alone after correction, and should be used as a complementary research biomarker rather than a diagnostic test.

Published 2026年9月23日