聽覺正常與失聰小鼠聽覺皮層之全腦神經解剖連結圖譜

// Brain-wide mapping of neuroanatomical connections to the auditory cortex of hearing and deaf mice

以交叉遺傳追蹤繪製A1（原始聽覺皮層）全腦輸入｜先天性失聰小鼠自基底內側杏仁核、MGv（聽覺丘腦核心）與前側聽覺丘腦核輸入顯著減少，其他丘腦核與非聽覺皮層通路多數保留，顯示失聰選擇性改變A1連結，對聽力恢復策略具指導價值

// Using an intersectional genetic tracing approach, the study mapped brainwide inputs to primary auditory cortex in congenitally deaf mice and hearing littermates. Deaf mice showed significant reductions in inputs from the basomedial amygdala, the core of the medial geniculate nucleus, and anterior auditory thalamic nuclei, while inputs from other thalamic nuclei and non-auditory cortical regions were largely preserved. Thus, congenital deafness selectively alters some auditory-cortex connections but leaves many pathways intact, which may influence and inform strategies to restore hearing.

Published 2026年9月26日